3rd Scientific Meeting of the European Network for the Study of Adrenal Tumours (ENS@T)

Friday 8 October 2004

11.00h-13.00h Business meeting 1 (ENS@T Steering Committee only)
Review of feedback and outline protocols of the ENS@T consensus working groups PHEO and ACC

13.00-13.55h Buffet Lunch

13.55h Welcome Paul M. Stewart

14.00-15.45h Session I: Molecular basis of phaeochromocytomas
Chair: Pierre-François Plouin, France

14.00-14.15h Jochen Mundschenk, Magdeburg, Germany
Somatostatin receptor subtypes in human phaeochromocytoma: subcellular expression pattern and functional relevance for octreotide scintigraphy

14.15-14.30h Hendrik Lehnert, Magdeburg, Germany
hTERT and HSP90 as markers for malignancy in phaeochromocytomas

14.30-14.45h Martin Fassnacht, Würzburg, Germany
Does AKT play an essential role in the pathogenesis of phaeochromocytomas?

14.45-15.00h Lisa Simi, Florence, Italy
Founder SDHD mutation (Q109X) in four families affected by neural crest-derived tumours

15.00-15.15h Francesca Schiavi, Padua, Italy/Laurence Amar, Paris, France
Germline mutations in phaeochromocytomas and paragangliomas

15.15-15.30h Caroline D.E. Margetts, Birmingham, UK
Epigenetic analysis of HIC1, CASP8, FLIP, TSP1, DcR1, DcR2, DR4, DR5, KvDMR1, H19 and preferential 11p15.5 maternal allele loss in VHL and sporadic phaeochromocytomas

15.30-15.45h Laurence Strompf, Paris, France
The HIF-pathway and new candidate genes for paraganglioma and/or pheochromocytoma.

15.45-16.15h Tea

16.15-17.00h Lecture
Chair: Paul M. Stewart

"Regulation and dysregulation of aldosterone secretion"
William E. Rainey University of Texas Southwestern Medical Center Dallas, USA

17.00h-18.00h Business meeting 2 (ENS@T Steering Committee only)
Feedback/outline protocols of the ENS@T PAL WG

19.00h Bus transfer from Lucas House to Conference Dinner

19.30-23.00h Conference dinner
BANK Restaurant, Brindley Place, Birmingham

Saturday 9 October 2004

08.30h-9.30h Business meeting 3 (ENS@T Steering Committee only)
Review of feedback and outline protocols of the ENS@T INC/CUSH working group

09.30-10.30h Session II: Pathogenesis of adrenocortical tumours
Chair: Massimo Mannelli, Italy

Andrew B. Bicknell, Reading, UK
Activation of adrenal MAPK pathways by N-POMC peptides

O. Chabre, Grenoble, France
Transfer of the GIP-receptor gene in adrenocortical cells induces a benign tumoral phenotype after transplantation in mice.

GP Rossi, Padua, Italy
Telomerase gene expression in aldosterone-producing adenoma and carcinoma

Guillaume Assié, Villejuif, France
Transcriptome of the aldosterone producing adenoma: a SAGE approach

10.30-11.30h Discussion of a pan-European Tissue Collection: Database, IT, ethical and funding issues

Chair: Xavier Bertagna
Discussants: Bruno Allolio, Franco Mantero, Pierre-Francois Plouin

11.30-11.45h Coffee

11.45-13.00h Session III:
Diagnostic and therapeutic approaches to adrenocortical tumours
Chair: Bruno Allolio, Germany

11.45-12.00h Caroline Schirpenbach, München, Germany
Confirmatory testing in normokalaemic primary aldosteronism: the value of saline infusion test and urinary aldosterone metabolites

12.00-12.15h Sophie Leboulleux, Villejuif, France
18 FDG-PET in the work-up of adrenocortical carcinomas

12.15-12.30h Stefanie Hahner, Würzburg, Germany
Evidence for intraadrenal feedback regulation of steroidogenesis - lessons from adrenostatic compounds intended for use in adrenal imaging

12.30-12.45h Pietro Ferruzzi, Florence, Italy/Beatrice Macino, Padua, Italy
Effects of PPARgamma agonists on adrenal cancer cell growth and invasiveness

12.45-13.00h Felix Beuschlein, Freiburg, Germany
PPARgamma agonists - a new treatment option for adrenocortical carcinoma?

13.00-14.00h Buffet Lunch and End of meeting