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Clinical features of adrenocortical carcinomas, prognostic factors, and the effect of mitotane therapy.
Luton , J.-P., Cerdas, S., Billaud, L., Thomas, G., Guilhaume, B., Bertagna, X., Laudat, M.-H., Louvel, A., Chapuis, Y., Blondeau, P., Bonnin, A., and Bricaire, H.
N. Engl. J. Med. 322 :1195-1201, 1990
 
Loss of expression of the ubiquitous transcription factor cAMP response element-binding protein (CREB) and compensatory averexpression of the activator CREM tau in the human adrenocortical cell line H295R.
Groussin, L., J. F. Massias, X. Bertagna, and J. Bertherat.
J. Clin. Endocrinol. Metab. 85 : 345- 354, 2000
 
Molecular markers and long term recurrences in alarge cohort of patients with sporadic adrenocortical tumors
Gicquel, C., Bertagna, X., Gaston, V., Coste, J., Louvel, A., Baudin, E., Bertherat, J., Chapuis, Y., Duclos, J.-M., Schlumberger, M., Plouin, P.-F., Luton, J.-P., and Le Bouc, Y.
Cancer Res. 18 : 6762-6767, 2001.
 
Mutations of the PRKAR1A Gene in Cushing's Syndrome due to Sporadic Primary Pigmented Nodular Adrenocortical Disease.
Groussin L, Jullian E, Perlemoine K, Louvel A, Leheup B, Luton JP, Bertagna X, Bertherat J.
J Clin Endocrinol Metab. 87 : 4324-9. 2002
 
Adrenal incidentalomas.

Bertherat J, Mosnier-Pudar H, Bertagna X.

Curr Opin Oncol.14 : 58-63. (Review) 2002
 
Molecular analysis of the cyclic AMP-dependent protein kinase A (PKA) regulatory subunit 1A (PRKAR1A) gene in patients with Carney complex and Primary Pigmented Nodular Adrenocortical Disease (PPNAD) reveals novel mutations and clues for pathophysiology : augmented PKA signaling is associated with adrenal tumorigenesis in PPNAD.
Groussin L, Kirschner LS, Vincent-Dejean C, Perlemoine K, Jullian E, Delemer B, Zacharieva S, Pignatelli D, Carney JA, Luton JP, Bertagna X, Stratakis CA, and Bertherat J.
Am J Hum Genet (in press 2002)
 
Telomerase activity is significantly enhanced in malignant adrenocortical tumors in comparison to benign adrenocortical adenomas.
Mannelli M, Gelmini S, Arnaldi G, Becherini L, Bemporad D, Crescioli C, Pazzagli M, Mantero F, Serio M, Orlando C.
J Clin Endocrinol Metab. 2000;85:468- 470.
 
Aberrant interleukin-1 receptors in a cortisol-secreting adrenal adenoma causing Cushing's syndrome.
Willenberg HS, Stratakis CA, Marx C, Ehrhart-Bornstein M, Chrousos GP, Bornstein SR.
N Engl J Med. 1998 Jul 2;339(1):27-31.
 
The tumour suppressor protein vHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER, Ratcliffe PJ.
Nature. 1999 May 20;399(6733):271-5.
 
Adrenomedullary dysplasia and hypofunction in patients with classic 21-hydroxylase deficiency.
Merke DP, Chrousos GP, Eisenhofer G, Weise M, Keil MF, Rogol AD, Van Wyk JJ, Bornstein SR.
N Engl J Med. 2000 Nov 9;343(19):1362-8.
 
Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma
Gimm O, Armanios M, Dziema H, Neumann HP, Eng C.
Cancer Res. 2000 Dec 15;60(24):6822-5.
 
Adenoviral vectors can impair adrenocortical steroidogenesis: Clinical implications for natural infections and gene therapy.
Alesci S, Ramsey WJ, Bornstein SR, Chrousos GP, Hornsby PJ, Benvenga S, Trimarchi F, Ehrhart-Bornstein M.
Proc Natl Acad Sci U S A. 2002 May 28;99(11):7484-9.
 
Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth.
Bicknell AB, Lomthaisong K, Woods RJ, Hutchinson EG, Bennett HP, Gladwell RT, Lowry PJ.
Cell. 2001 Jun 29;105(7):903-12.
 
Germ-line mutations in nonsyndromic pheochromocytoma.

Neumann HP, Bausch B, McWhinney SR, Bender BU, Gimm O, Franke G, Schipper J, Klisch J, Altehoefer C, Zerres K, Januszewicz A, Smith WM, Munk R, Manz T, Glaesker S, Apel TW, Treier M, Reincke M, Walz MK, Hoang-Vu C, Brauckhoff M, Klein-Franke A, Klose P, Schmidt H, Maier-Woelfle M, Peczkowska M, Szmigielski C, Eng C

N Engl J Med. 2002 May 9;346(19):1459-66.
 
Characterization of a serine protease that cleaves pro-gamma-melanotropin at the adrenal to stimulate growth.
Bicknell AB, Lomthaisong K, Woods RJ, Hutchinson EG, Bennett HP, Gladwell RT, Lowry PJ.
Cell. 2001 Jun 29;105(7):903-12.